¹⁵N and ¹³C NMR studies of the interaction of cyanide ion with gold (I) drugs

(1993) ¹⁵N and ¹³C NMR studies of the interaction of cyanide ion with gold (I) drugs. Masters thesis, King Fahd University of Petroleum and Minerals.


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¹⁵N NMR studies of the interaction of ¹⁵N cyanide ion with gold(I) thiomalate (autm) and gold(I)thioglucose (Autg) have been carried out at Ph* 7.40. The chemical shifts of the two ¹⁵N containing species Au(C¹⁵N)2- and RS-Au-C¹⁵N⁻ (where RS⁻ = tum- or tg-) were identified. From the broadened ¹⁵N NMR signals, approximate lifetimes of the RS-Au-CN- species were calculated. Captopril (Hcap) with gold(I) forms a 1:1 crystalline complex Au(K)cap. The exchange reactions of thiomalate and cyanide with Au(I)cap have been studied using ¹³C NMR spectroscopy. Au(I)cap forms a very high molecular weight polymer. Thiomalate and CN⁻ both bind to Au(I)cap, however, as expected, CN binds more strongly. Both the cis and trans Au(I)cap isomers were observed upon the addition of ¹³CN⁻ to A(I)cap solution. The ligand scrambling reaction of R₃PAuC ¹⁵N to form (R₃P)₂Au⁺ and Au(C¹⁵N)₂⁻ has been studied for R = Me, Et, i-Pr, and Ph. Two ³¹P NMR resonances were observed for (R₃P)₂Au⁺ species. Howere, for the ¹⁵N NMR, apart from ET₃PAuC¹⁵N(R = Me, Ph).

Item Type: Thesis (Masters)
Subjects: Chemistry
Department: College of Chemicals and Materials > Chemistry
Committee Advisor: Isab, A. A.
Committee Members: Al-Arfaj, A. R. and Perzanowski, Herman
Depositing User: Mr. Admin Admin
Date Deposited: 22 Jun 2008 13:52
Last Modified: 01 Nov 2019 13:52
URI: http://eprints.kfupm.edu.sa/id/eprint/9919