Synthesis of New 4-Aryl-1-(Biarylmethylene) Piperidine Ligands, Structurally Related to SLV-313.

Synthesis of New 4-Aryl-1-(Biarylmethylene) Piperidine Ligands, Structurally Related to SLV-313. Masters thesis, King Fahd University of Petroleum and Minerals.

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Arabic Abstract

تم تحضير سلسلة جديدة من مشتقات4-aryl-1-(biarylmethylene)piperidines .SLV- والتي تشابه تركيبي اً لمادة 313 بواسطة تفاعل سوزوكي -ماياورا بين بورونات الفنيال الحلقية المشتقة من تراي فلايت الفنايل لرباعي ھايدروالبيريدين مع ھاليدات الاريل والذي انتج مادة ٤-اريل البايبريدين تم تفاعل الاخير مع الديھايد ثنائي الاريل المناسب لإصطناع المركبات الجديدة المذكورة في الرسالة

English Abstract

A series of new 4-aryl-1-(biarylmethylene)piperidines have been synthesized. They are structurally related to SLV-313, a potential atypical antipsychotic agent with potent D2 receptor antagonist and5-HT1A receptor agonist properties. Suzuki-Miyaura reaction of cyclic vinyl boronates, derived from the vinyl triflates of N-protected tetrahydropyridines, with appropriate aryl halides yielded 4-arylpiperidines.The reductive amination of the latter with suitable biarylaldehydes accomplished the synthesis of the new compounds.

Item Type: Thesis (Masters)
Subjects: Chemistry
Divisions: College Of Sciences > Chemistry Dept
Committee Advisor: Ullah, Nisar Ullah
Committee Members: Shaikh, Shaikh Asrof Ali and Quraishi, Ahsanulhaq Quraishi
Depositing User: Ali Ahmed Alshaheri (g200704570)
Date Deposited: 03 Oct 2012 11:35
Last Modified: 01 Nov 2019 18:36
URI: http://eprints.kfupm.edu.sa/id/eprint/138780