Chemometric optimization and kinetic developments in flow injection analysis

(1996) Chemometric optimization and kinetic developments in flow injection analysis. PhD thesis, King Fahd University of Petroleum and Minerals.

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English Abstract

Chemometric optimization methodologies have been utilized for the development of quantitative methods of analysis of some drugs using flow injection (F1) techniques. Super modified simplex procedures together with statistical design techniques have been used for optimization and modeling of response surface. The sequential optimization has validated the flow injection methods proposed with excellent reproducibility, high sensitivity, and a wide dynamic range. A sampling frequency of not less than 120 h⁻¹ was obtained for all methods developed. Sequential injection (SI) technique has been sucessfully applied for the determination of reaction stiochiometry and formation constant. The 1:1 and 1: 2 metal : drug mole ratio have been obtained for the complexation of some phenothiazines with palladium (II) in hydrochloric acid media and for the complexation of some flouroquinolones with iron(III) in sulfuric acid media respectively. For the first time, sequential injection technique has been employed for full kinetics investigation resulting in proposing reasonable mechanism of reactions and adopting kinetic methods of analysis. The complexation reaction of bromazepam with iron(II) was studied in hydrochloric acid media. The orders of the reaction with respect to each reactant were determined and a consistent reaction rate law was offered.

Item Type: Thesis (PhD)
Subjects: Chemistry
Divisions: College Of Sciences > Chemistry Dept
Committee Advisor: Sultan, Salah-Eldin M.
Committee Members: Perzanowski, Herman and Abdennabi, Abddullah A. and Zettili, Noureddine and Hwang, J.
Depositing User: Mr. Admin Admin
Date Deposited: 22 Jun 2008 17:03
Last Modified: 01 Nov 2019 17:00
URI: http://eprints.kfupm.edu.sa/id/eprint/10390