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Development and applications of quaternary ammonium (QA) membrane electrodes in pharmaceutical preparation and in bioavailability of Prostaglandin E1 and Deoxycholate

K. Gupta, Vinod and K. Pal, Manoj and K. Singh, Ashok (2009) Development and applications of quaternary ammonium (QA) membrane electrodes in pharmaceutical preparation and in bioavailability of Prostaglandin E1 and Deoxycholate. ELECTROCHIMICA ACTA.

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Abstract

The two novel ion-pairs (PB-TPB and NB-TPB) of quaternary ammonium drugs; propantheline bromide (PB), N,N-Diisopropyl-N-methyl-N-[2-(xanthen-9ylcarbonyloxy)ethyl] ammonium bromide and neostigmine bromide (NB), 3-(dimethylcarbamoyloxy) phenyl]-trimethylazanium have been synthesized, respectively and incorporated in poly (vinyl chloride)-based membrane electrodes for the quantification of propantheline bromide and neostigmine bromide in different pharmaceutical preparations. The influences ofmembranecompositionsonthepotentiometric responses ofmembrane electrodes have been found to substantially improve the performance characteristics. The best performance was reported with membranes having composition (w/w) of PB-TPB or NB-TPB (6%): PVC (34%): o-NPOE (60%). The proposed electrodes exhibit nernstian response in the concentration ranges of 2.1×10−7 M to 1.0×10−2Mand 4.4×10−7 Mto1.0×10−2Mwith detection limit of 1.5×10−7Mand 3.3×10−7 M, respectively. Both the membrane electrodes perform satisfactorily over pH ranges of (3.5–7.5 and 4.0–7.0) with fast response times (11 s and 13 s), respectively. These drugs (PB and NB)were further utilized as different ion-pairs of Prostaglandin E1 (PGE1) and Deoxycholate (DOC) in poly (vinyl chloride)-based membrane electrodes for the determination of bioavailability of Prostaglandin E1 and Deoxycholate in plasma of different patients.



Item Type:Article
Date:25 June 2009
Date Type:Publication
Subjects:Chemistry
Divisions:College Of Sciences > Chemistry Dept
Creators:K. Gupta, Vinod and K. Pal, Manoj and K. Singh, Ashok
Email:vinodfcy@gmail.com, UNSPECIFIED, UNSPECIFIED
ID Code:136164
Deposited By:Morshed Alam Bhuiyan
Deposited On:18 Oct 2009 17:20
Last Modified:12 Apr 2011 13:16

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